Type I feline coronavirus spike glycoprotein fails to recognize aminopeptidase N as a functional receptor on feline cell lines
2007
Feline Coronavirus Spike Protein and Its Receptor
publication
Evidence: moderate
Author Information
Author(s): Charlotte Dye, Nigel Temperton, Stuart G. Siddell
Primary Institution: University of Bristol
Hypothesis
Is feline aminopeptidase N a receptor for type I feline coronaviruses?
Conclusion
Feline aminopeptidase N does not function as a receptor for type I feline coronaviruses.
Supporting Evidence
- Type I feline coronavirus spike glycoprotein does not recognize feline aminopeptidase N as a receptor.
- Retroviral pseudotypes can be used to identify cellular receptors for type I feline coronaviruses.
- Feline aminopeptidase N is known to be a receptor for type II feline coronaviruses.
Takeaway
The study found that a specific protein in cats does not help a certain virus enter their cells, which means the virus needs a different way to infect.
Methodology
The study used retroviral pseudotypes to test the interaction of feline coronavirus spike proteins with various feline cell lines.
Limitations
The study may not account for all possible receptors or mechanisms of infection for type I feline coronaviruses.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website