Shock Wave Treatment in Composite Tissue Allotransplantation
Author Information
Author(s): Radu Christian Andreas MD, Kiefer Jurij MD, Horn Dominik MD, Rebel Martin MD, Koellensperger Eva MD, Gebhard Martha Maria MD, PhD, Ryssel Henning MD, Germann Guenter MD, Reichenberger Matthias Artur MD
Primary Institution: Department of Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Plastic and Hand Surgery of the University of Heidelberg, Heidelberg, Germany
Hypothesis
Can extracorporeal shock wave treatment delay rejection in composite tissue allotransplantation?
Conclusion
Shock wave treatment significantly delays rejection in composite tissue allotransplantation models.
Supporting Evidence
- Rejection occurred on average 7.12 days after transplantation in the shock wave group.
- Rejection was significantly delayed compared to control groups receiving no immunosuppression.
- No rejection was seen in groups receiving FK506 and prednisolone.
Takeaway
This study shows that using shock waves can help transplanted limbs last longer before being rejected by the body.
Methodology
50 allogeneic hindlimb transplantations were performed on rats, divided into 5 groups with different treatments.
Limitations
The study's findings may be limited by the experimental design and the use of a single ESW treatment.
Participant Demographics
Male Lewis and Brown-Norway rats, aged 7-15 weeks.
Statistical Information
P-Value
<0.01
Statistical Significance
p<0.01
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