Cloning of a gene (SR-A1), encoding for a new member of the human Ser/Arg-rich family of pre-mRNA splicing factors: overexpression in aggressive ovarian cancer
2001
Discovery of the SR-A1 Gene Linked to Aggressive Ovarian Cancer
publication
Author Information
Author(s): Scorilas A, Kyriakopoulou L, Katsaros D, Diamandis E P
Primary Institution: Mount Sinai Hospital, Toronto, Ontario, Canada
Hypothesis
Is the SR-A1 gene overexpressed in aggressive ovarian cancer?
Conclusion
The SR-A1 gene is overexpressed in a subset of clinically aggressive ovarian cancers.
Supporting Evidence
- The SR-A1 gene is expressed in all tissues tested, with highest levels in fetal brain and liver.
- The SR-A1 protein interacts with RNA polymerase II and is involved in pre-mRNA splicing.
- In certain cancer cell lines, the expression of SR-A1 increases with hormones like estrogens and androgens.
Takeaway
Scientists found a new gene called SR-A1 that is more active in some aggressive ovarian cancers, which might help us understand how these cancers grow.
Methodology
Positional cloning gene approach was used to identify the SR-A1 gene.
Digital Object Identifier (DOI)
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