A comparison of acellular dermal matrices (ADM) efficacy and complication profile in women undergoing implant-based breast reconstruction: a systematic review and network meta-analysis

2024

Comparing Acellular Dermal Matrices in Breast Reconstruction

Sample size: 7667 publication 10 minutes Evidence: moderate

Author Information

Author(s): Glynou Sevasti Panagiota, Sousi Sara, Cook Hannah, Zargaran Alexander, Zargaran David, Mosahebi Afshin

Primary Institution: London School of Medicine and Dentistry, Queen Mary University of London, London, UK

Hypothesis

What are the efficacy and complication profiles of different acellular dermal matrices (ADMs) used in implant-based breast reconstruction?

Conclusion

The overall complication profiles of ADMs used in implant-based breast reconstruction are similar, except for the higher risks associated with AlloDerm FD compared to RTU.

Supporting Evidence

51 studies were captured by the search, of which 27 were included in the network meta-analysis.
Porcine ADMs had the highest rate of seroma formation (10.3%) and of haematoma formation (2.7%).
Implant failure was highest in AlloDerm FD ADMs (11.8%), followed by Porcine ADMs (11.2%).
Infections were most common in Porcine (11.2%) and AlloDerm FD ADMs (11.0%).
AlloDerm FD showed significantly higher risks of infection, explantation, and wound dehiscence compared to AlloDerm RTU.

Takeaway

This study looked at different materials used in breast surgery to see which ones work best and found that most are similar, but one type has more problems.

Methodology

A systematic review and network meta-analysis were conducted, analyzing 51 studies with a focus on short- and long-term complications associated with various ADMs.