Angiogenesis and Macrophage Density in B-cell Non-Hodgkin's Lymphomas
Author Information
Author(s): Vacca A, Ribatti D, Ruco L, Giacchetta F, Nico B, Quondamatteo F, Ria R, Iurlaro M, Dammacco F
Primary Institution: University of Bari Medical School
Hypothesis
Angiogenesis and macrophage density increase with the progression of B-cell non-Hodgkin's lymphomas.
Conclusion
The study found that both angiogenesis and macrophage density are significantly higher in B-cell non-Hodgkin's lymphomas compared to benign lymphadenopathies.
Supporting Evidence
- Both microvessel and macrophage counts were significantly higher in B-cell non-Hodgkin's lymphomas compared to benign lymphadenopathies.
- Higher counts of microvessels and macrophages were found in high-grade lymphomas compared to low-grade lymphomas.
- A close spatial association between microvessels and macrophages was observed.
Takeaway
This study shows that as certain lymphomas get worse, they have more blood vessels and immune cells that help them grow.
Methodology
Node biopsies of 30 benign lymphadenopathies and 71 B-cell non-Hodgkin's lymphomas were analyzed for microvessel and macrophage counts using immunohistochemistry and morphometric analysis.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website