Body Composition and Recurrence Risk in Triple-Negative Breast Cancer
Author Information
Author(s): De Vis Jill B., Wang Cong, Nguyen Kirsten V., Sun Lili, Jia Brigitte, Sherry Alexander D., Alford-Holloway Mason N., Balbach Meredith L., Koyama Tatsuki, Bapsi Chakravarthy A., Rafat Marjan
Primary Institution: Vanderbilt University Medical Center
Hypothesis
VSR is a stronger predictor of recurrence compared with BMI in patients with TNBC.
Conclusion
VSR was associated with a significant risk of distant recurrence and may be a prognostic biomarker.
Supporting Evidence
- VSR was significantly associated with an increased risk of distant recurrence.
- BMI was not associated with any recurrence risk.
- Anthropometric measures poorly correlate with VSR.
- VSR may be a more sensitive biomarker for disease recurrence.
Takeaway
This study found that a specific body fat measurement called VSR can help predict if women with a certain type of breast cancer will have a recurrence.
Methodology
The study analyzed body composition measures from CT images and assessed associations with recurrence risk using statistical models.
Potential Biases
The findings may not be generalizable due to the specific demographic of the study population.
Limitations
The study had a small sample size and was skewed towards an obese Caucasian cohort.
Participant Demographics
Median age was 54 years, with 73% Caucasian, 22% Black, and 2% Hispanic.
Statistical Information
P-Value
0.041
Confidence Interval
95% CI: 1.06–17.02
Statistical Significance
p = 0.041
Digital Object Identifier (DOI)
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