Effect of cromoglycate on gas changes during bronchial challenge in asthmatic children
Author Information
Author(s): L. Mappa, S. Bavaro, G. Moramarco, D. Torio, D. Falciatore, G. Ciccarone, L. Cicciomessere, N. Rigillo
Primary Institution: Istituto di Pediatria Clinica e Sociale, University of Bari Policlinico
Hypothesis
What is the effect of cromoglycate on transcutaneous oxygen and carbon dioxide levels during bronchial challenge in asthmatic children?
Conclusion
UNCDW induces nonspecific broncho-constriction in asthmatic children, and treatment with cromoglycate normalizes the time course of carbon dioxide levels and reduces the drop in oxygen levels during and after the challenge.
Supporting Evidence
- Mean tcpCO values during the challenge were significantly lower than the corresponding steady state.
- Mean tcpO values remained significantly decreased from the fifth minute of the UNCDW challenge to the end of the observation period.
- After treatment with cromoglycate, the mean tcpCO values during UNCDW did not change significantly from those of steady state.
- The control children treated with saline showed mean tcpCO and tcpO values which were significantly different from those of the steady state.
Takeaway
The study tested how a medicine called cromoglycate affects breathing in kids with asthma when they are exposed to a special mist. It found that the medicine helps keep their breathing more normal.
Methodology
Eighteen asthmatic children were tested with UNCDW, then randomly assigned to inhale either cromoglycate or saline for 8 days before repeating the test.
Participant Demographics
18 asthmatic children (8 males, 10 females) aged 3 to 12 years.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
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