High-molecular-weight hyaluronan as a treatment for lung injury in sepsis
Author Information
Author(s): Liu Yung-Yang, Lee Cheng-Hung, Dedaj Rejmon, Zhao Hang, Mrabat Hicham, Sheidlin Aviva, Syrkina Olga, Huang Pei-Ming, Garg Hari G, Hales Charles A, Quinn Deborah A
Primary Institution: Massachusetts General Hospital
Hypothesis
HMW HA would inhibit lung injury associated with sepsis and mechanical ventilation.
Conclusion
HMW HA may prove to be an effective treatment strategy for sepsis-induced lung injury with mechanical ventilation.
Supporting Evidence
- HMW HA completely blocked lung neutrophil and monocyte infiltration.
- HMW HA reduced lung injury scores significantly compared to LMW HA.
- HMW HA inhibited MIP-2 and TNFα production in a dose-dependent manner.
Takeaway
This study found that a special type of hyaluronan can help protect the lungs from damage caused by infections and breathing machines.
Methodology
The study used Sprague-Dawley rats divided into groups to test the effects of HMW HA and LMW HA on lung injury caused by mechanical ventilation and LPS infusion.
Limitations
The study could not match molarity between HMW HA and LMW HA due to solubility issues.
Participant Demographics
Sprague-Dawley rats, weighing between 185 and 225 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website