Microdialysis and Response During Regional Chemotherapy
Author Information
Author(s): Thompson J F, Siebert G A, Anissimov Y G, Smithers B M, Doubrovsky A, Anderson C D, Roberts M S
Primary Institution: Department of Surgery, University of Sydney and Sydney Melanoma Unit, Royal Prince Alfred Hospital, Sydney, NSW, Australia
Hypothesis
This study sought to use a microdialysis technique to relate clinical and biochemical responses to the time course of melphalan concentrations in patients undergoing regional chemotherapy.
Conclusion
Microdialysis is effective for measuring cytotoxic drug concentrations during isolated limb infusion, which may improve drug dose calculations.
Supporting Evidence
- Peak and mean concentrations of melphalan were significantly higher in plasma than in subcutaneous or tumour microdialysate.
- Tumour response in the whole group showed a partial response in 53.8% of patients.
- There was a significant association between tumour response and melphalan concentrations measured over time in subcutaneous microdialysate.
Takeaway
The study looked at how a special technique can help doctors see how much medicine is in the body during treatment for limb cancers.
Methodology
Patients undergoing isolated limb infusion for limb malignancies were monitored for melphalan concentrations in plasma and tissues using microdialysis.
Participant Demographics
Patients with various limb malignancies including melanoma, malignant fibrous histiocytoma, Merkel cell tumour, and osteosarcoma.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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