Recurrence Hazard in Breast Cancer Patients After Surgery
Author Information
Author(s): Kiba Takayoshi, Inamoto Takashi, Nishimura Tsutomu, Ueno Masaya, Yanagihara Kazuhiro, Teramukai Satoshi, Kato Hironori, Toi Masakazu, Fukushima Masanori
Primary Institution: Kyoto University Hospital
Hypothesis
Does the hazard of recurrence differ between ER positive and negative breast cancer patients over time?
Conclusion
The study found that the hazard of recurrence reverses between ER positive and negative breast cancer patients beyond 3 years after surgery.
Supporting Evidence
- ER-positive patients had a better overall survival rate compared to ER-negative patients.
- The hazard of recurrence was higher for ER-negative patients in the first 2 years after surgery.
- Beyond 3 years, the hazard of recurrence was higher for ER-positive patients.
Takeaway
At first, women with ER-negative breast cancer have a higher chance of recurrence, but after 3 years, women with ER-positive cancer have a higher chance.
Methodology
The study analyzed survival data of 742 breast cancer patients using multivariate analysis to assess prognostic factors.
Potential Biases
There may be biases related to the selection of patients and treatment variations over the years.
Limitations
The study is limited by its retrospective design and the potential for confounding factors.
Participant Demographics
All participants were female breast cancer patients aged 21 to 80, with stages I-III of pTNM.
Statistical Information
P-Value
0.012
Confidence Interval
95% CI
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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