Basic Fibroblast Growth Factor and Non-Hodgkin's Lymphoma Outcomes
Author Information
Author(s): Pazgal I, Zimra Y, Tzabar C, Okon E, Rabizadeh E, Shaklai M, Bairey O
Primary Institution: Institute of Hematology and Felsenstein Medical Research Center, Rabin Medical Center
Hypothesis
Does the expression of basic fibroblast growth factor (bFGF) and its receptor correlate with patient outcomes in non-Hodgkin's lymphoma?
Conclusion
The expression of basic fibroblast growth factor and its receptor in non-Hodgkin's lymphoma is associated with worse patient outcomes.
Supporting Evidence
- Patients expressing bFGF had significantly worse progression-free and overall survival.
- Patients with positive FGFR-1 expression were less likely to achieve complete remission.
Takeaway
This study found that patients with non-Hodgkin's lymphoma who have higher levels of a certain growth factor tend to do worse in terms of survival.
Methodology
Serum bFGF levels were measured in patients before and after treatment, and biopsy specimens were analyzed for bFGF and FGFR-1 expression.
Limitations
The study had a small and heterogeneous sample size.
Participant Demographics
58 adult patients, 45% male and 55% female, mean age 64.5 years.
Statistical Information
P-Value
0.003
Statistical Significance
p=0.003
Digital Object Identifier (DOI)
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