Somatic mutations in the p53 gene and prognosis in breast cancer: a meta-analysis
1999
p53 Gene Mutations and Breast Cancer Prognosis
Sample size: 2319
publication
Evidence: moderate
Author Information
Author(s): Pharoah P D P, Day N E, Caldas C
Primary Institution: University of Cambridge
Hypothesis
Do somatic mutations in the p53 gene affect prognosis in breast cancer?
Conclusion
Somatic mutations in the p53 gene are associated with poorer survival outcomes in breast cancer patients.
Supporting Evidence
- Eleven studies investigated overall survival in a total of 2319 unselected cases.
- The combined relative hazard estimate for p53 mutations was 2.0.
- For node-negative patients, the combined relative hazard was 1.7.
- For node-positive breast cancer, the combined risk estimate was 2.6.
Takeaway
If a breast cancer patient has a mutation in the p53 gene, they might not do as well as others without the mutation.
Methodology
Meta-analysis of eleven studies investigating the association between p53 mutations and breast cancer prognosis.
Limitations
Different studies produced varying estimates of risk, and not all results were statistically significant.
Participant Demographics
Unselected cases of breast cancer.
Statistical Information
Confidence Interval
1.7–2.5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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