Study on Genetic Factors and Coronary Atherosclerosis
Author Information
Author(s): Chen Suet Nee, Ballantyne Christie M, Gotto Antonio M Jr, Marian Ali J
Primary Institution: Center for Cardiovascular Genetics, Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center
Hypothesis
The SNPs at the 9p21 locus are associated with the severity and progression of coronary atherosclerosis.
Conclusion
The 4 SNPs at the 9p21 locus do not have major effects on the severity or progression of coronary atherosclerosis.
Supporting Evidence
- The study found no significant association between SNPs at the 9p21 locus and coronary atherosclerosis severity.
- Only Caucasians were included, comprising 90% of the study population.
- The study used quantitative coronary angiography to assess atherosclerosis.
Takeaway
The study looked at certain genes to see if they affect heart disease, but they found no strong link.
Methodology
The study analyzed SNPs in a population with coronary artery disease using quantitative coronary angiography.
Limitations
The study only included Caucasians, which may limit the generalizability of the findings.
Participant Demographics
332 Caucasian individuals aged 35 to 75, with a majority being male (84%).
Digital Object Identifier (DOI)
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