Modification of Tumour Blood Flow Using Angiotensin II
Author Information
Author(s): G.M. Tozer, K.M. Shaffi
Primary Institution: CRC Gray Laboratory
Hypothesis
Can angiotensin II modify blood flow in tumours and normal tissues?
Conclusion
Angiotensin II infusion reduces blood flow to the P22 tumour while increasing vascular resistance.
Supporting Evidence
- Angiotensin II increased mean arterial blood pressure significantly.
- Blood flow to the tumour was reduced to about 80% of control values.
- Vascular resistance increased significantly in all tissues studied.
Takeaway
This study looked at how a drug called angiotensin II affects blood flow in tumours. It found that while it can change blood flow, it actually reduces the blood flow to the tumour itself.
Methodology
The study measured blood flow and vascular resistance in BD9 rats using angiotensin II at various doses.
Potential Biases
Potential bias due to inter-transplant variation in blood flow.
Limitations
The study was limited to a specific tumour type and may not generalize to all tumours.
Participant Demographics
Male BD9 rats aged 10 to 12 weeks.
Statistical Information
P-Value
0.01
Statistical Significance
p<0.05
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