Association between serum vitamin D and severe headache or migraine: A population-based analysis
2025

Vitamin D and Migraine: A Study

Sample size: 9142 publication 10 minutes Evidence: moderate

Author Information

Author(s): Hao Shunfa, Qian Renyi, Chen Yiru, Liu Jingfang, Xu Xiaoyan, Guan Yunxiang

Primary Institution: The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, China

Hypothesis

Is there a relationship between serum vitamin D levels and the prevalence of migraine?

Conclusion

The study found a significant negative correlation between serum vitamin D levels and the prevalence of migraine in American adults.

Supporting Evidence

  • 20.53% of participants suffered from migraine.
  • Participants in the highest quartile of serum vitamin D levels had a 16% lower prevalence of migraine compared to those in the lowest quartile.
  • The study controlled for various confounders including age, gender, and race.

Takeaway

This study looked at how vitamin D levels might affect headaches. It found that people with higher vitamin D levels had fewer migraines.

Methodology

The study analyzed data from the NHANES survey, using logistic regression to examine the relationship between serum vitamin D levels and migraine prevalence.

Potential Biases

Potential recall bias due to reliance on self-reported migraine data.

Limitations

The study's cross-sectional design limits the ability to establish causality, and self-reported data may introduce bias.

Participant Demographics

Participants were adults from the NHANES survey, with a diverse demographic including various races and education levels.

Statistical Information

P-Value

0.04

Confidence Interval

95% CI 0.71–0.99

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1371/journal.pone.0313082

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