Study on Acute Empyema in Japan
Author Information
Author(s): Asai Nobuhiro, Ohashi Wataru, Shibata Yuichi, Sakanashi Daisuke, Kato Hideo, Hagihara Mao, Suematsu Hiroyuki, Mikamo Hiroshige
Primary Institution: Aichi Medical University Hospital
Hypothesis
The isolation of potentially drug-resistant pathogens could indicate dysbiosis in patients with acute empyema.
Conclusion
Higher Charlson comorbidity index scores and isolation of potentially drug-resistant pathogens are independent poor prognostic factors for in-hospital mortality among empyema patients.
Supporting Evidence
- Patients with higher CCI scores had worse outcomes.
- Isolation of PDR pathogens was linked to higher mortality.
- Healthcare-associated empyema had poorer prognosis than community-acquired empyema.
- All patients who underwent surgical treatment survived.
Takeaway
This study looked at patients with a serious lung infection called empyema and found that those with more health problems and certain germs in their bodies were more likely to die in the hospital.
Methodology
A long-term retrospective cohort study evaluating bacterial etiology and prognostic factors of acute empyema from 2008 to 2022.
Potential Biases
Selection bias may have occurred due to the retrospective nature and small sample size.
Limitations
The study is retrospective, conducted at a single center, and may not reflect all empyema patients in the community.
Participant Demographics
Median age was 72 years, with 76% male and 35% having malignancy as an underlying disease.
Statistical Information
P-Value
p = 0.009 for high CCI score; p = 0.011 for isolation of PDR pathogens
Confidence Interval
95% CI 1.7–45.6 for high CCI score; 95% CI 1.7–59.8 for isolation of PDR pathogens
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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