Effects of Rosa damascena on Neurite Growth in Alzheimer's Disease
Author Information
Author(s): Suresh Awale, Chihiro Tohda, Yasuhiro Tezuka, Makoto Miyazaki, Shigetoshi Kadota
Primary Institution: University of Toyama
Hypothesis
Drugs activating neurite outgrowth might induce neuronal reconstruction and help in the recovery of brain function.
Conclusion
The chloroform extract of Rosa damascena significantly induced neurite outgrowth and inhibited Aβ(25–35)-induced atrophy and cell death.
Supporting Evidence
- The chloroform extract of Rosa damascena significantly induced neurite outgrowth activity.
- The isolated compound from the extract protected against Aβ(25–35)-induced atrophy.
- The length of dendrites in cells treated with the compound was comparable to those treated with nerve growth factor.
Takeaway
This study found that a rose extract can help brain cells grow and recover from damage caused by a harmful protein related to Alzheimer's disease.
Methodology
The study involved extracting compounds from Rosa damascena and testing their effects on cultured rat cortical neurons exposed to Aβ(25–35).
Limitations
Further studies are required to isolate and identify other active constituents and their effects.
Participant Demographics
Rat cortical neurons were used in the experiments.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website