Prognostic role of p27Kip1 and apoptosis in human breast cancer
1999
Prognostic Role of p27Kip1 and Apoptosis in Breast Cancer
Sample size: 181
publication
Evidence: moderate
Author Information
Author(s): Wu J, Shen Z-Z, Lu J-S, Jiang M, Han Q-X, Fontana J A, Barsky S H, Shao Z-M
Primary Institution: Cancer Hospital/Cancer Institute, Shanghai Medical University
Hypothesis
The study investigates the relationship between apoptosis, p27Kip1 expression, and the biological behavior of breast cancer.
Conclusion
Low levels of p27 and apoptotic index are associated with lymph node metastasis and decreased patient survival in breast cancer.
Supporting Evidence
- High histological grade and high p53 levels are associated with low apoptosis and low p27 levels.
- Low levels of p27 and apoptotic index correlate with lymph node metastasis and decreased survival.
- In node-negative patients, p27 has prognostic value for relapse-free and overall survival.
Takeaway
This study found that certain markers in breast cancer can help predict how aggressive the cancer is and whether patients might benefit from chemotherapy.
Methodology
The study retrospectively examined apoptosis, p27Kip1, and p53 expression in breast cancer specimens.
Digital Object Identifier (DOI)
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