Trypsin and Ovarian Cancer: Understanding the Connection
Author Information
Author(s): Paju A, Sorsa T, Tervahartiala T, Koivunen E, Haglund C, Leminen A, Wahlström T, Salo T, Stenman U-H
Primary Institution: Helsinki University Central Hospital
Hypothesis
High concentrations of trypsinogen are associated with the activation of proMMP-9 and proMMP-2 in ovarian tumor cyst fluids.
Conclusion
The study found that high trypsin concentrations are linked to the activation of MMP-9, while they are inversely related to MMP-2 activation in ovarian tumor cyst fluids.
Supporting Evidence
- High trypsin concentrations were significantly associated with the activation of MMP-9.
- Trypsin concentrations were inversely associated with the activation of MMP-2.
- Immunohistochemical analysis showed expression of trypsinogen-2 in ovarian tumor tissue.
Takeaway
This study shows that trypsin might help cancer cells spread by activating certain proteins, but it can also have the opposite effect on another protein.
Methodology
Zymography and immunofluorometric analysis were used to study cyst fluids, along with immunohistochemical analysis of ovarian tumor tissue.
Statistical Information
P-Value
p=0.003–0.05 for MMP-9; p=0.01–0.02 for MMP-2
Statistical Significance
p=0.003–0.05 for MMP-9; p=0.01–0.02 for MMP-2
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website