The laminin-derived peptide YIGSR (Tyr–Ile–Gly–Ser–Arg) inhibits human pre-B leukaemic cell growth and dissemination to organs in SCID mice
1999
YIGSR Peptide Inhibits Leukaemia Cell Growth
Sample size: 9
publication
Evidence: moderate
Author Information
Author(s): Yoshida N, Ishii E, Nomizu M, Yamada Y, Mohri S, Kinukawa N, Matsuzaki A, Oshima K, Hara T, Miyazaki S
Primary Institution: Saga Medical School
Hypothesis
Does the multimeric YIGSR peptide have an anti-proliferative effect and prevent metastasis of human pre-B acute lymphoblastic leukaemia cells in SCID mice?
Conclusion
The multimeric YIGSR peptide significantly inhibits the growth and spread of leukaemic cells in mice.
Supporting Evidence
- The YIGSR peptide significantly inhibited leukaemic cell colony formation in vitro.
- In vivo, Ac-Y16 suppressed the weight of subcutaneous tumours in a dose-dependent manner.
- Leukaemic infiltration in all organs was significantly inhibited with 1.5–2.0 mg of Ac-Y16.
Takeaway
A special peptide can help stop leukaemia cells from growing and spreading in mice.
Methodology
In vitro studies and in vivo experiments in SCID mice were conducted to assess the effects of the YIGSR peptide on leukaemic cell growth and metastasis.
Participant Demographics
SCID mice were used in the study.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website