Adamantane-Resistant Influenza Infection During the 2004–05 Season
Author Information
Author(s): Rahman Mahbubur, Bright Rick A., Kieke Burney A., Donahue James G., Greenlee Robert T., Vandermause Mary, Balish Amanda, Foust Angela, Cox Nancy J., Klimov Alexander I., Shay David K., Belongia Edward A.
Primary Institution: Marshfield Clinic Research Foundation
Hypothesis
Infections caused by adamantane-resistant and susceptible influenza A viruses have not been compared.
Conclusion
The study found that adamantane resistance did not significantly alter the clinical symptoms or duration of illness in patients.
Supporting Evidence
- Adamantane resistance was present in 72 (47%) of 152 influenza A isolates.
- The median age was 43.6 years among patients with resistant isolates.
- Children 6–23 months had a significantly higher proportion of adamantane-resistant infections (70%) compared to adults over 65 (39%).
- Clinical features and duration of illness were similar for both resistant and susceptible strains.
Takeaway
This study looked at how a type of flu virus that resists a common medicine affects sick people, and it found that it doesn't make them feel worse than the regular flu.
Methodology
The study compared clinical and demographic characteristics of patients infected with adamantane-susceptible or -resistant strains of influenza A during the 2004–05 season.
Limitations
The study's power to detect differences in hospitalization rates was low.
Participant Demographics
Participants included children 6–23 months, adults over 65, and high-risk individuals aged 24 months to 64 years.
Statistical Information
P-Value
0.002
Confidence Interval
1.2–2.6
Statistical Significance
p = 0.002
Digital Object Identifier (DOI)
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