Kihi-to Improves Memory and Neurite Loss in Alzheimer's Model Mice
Author Information
Author(s): Tohda Chihiro, Naito Rie, Joyashiki Eri
Primary Institution: University of Toyama
Hypothesis
Kihi-to can improve memory deficits and promote neurite growth and synapse reconstruction in Alzheimer's disease model mice.
Conclusion
Kihi-to clearly improved memory impairment and losses of neurites and synapses.
Supporting Evidence
- Kihi-to administration improved memory acquisition and retention in Aβ(25–35)-injected mice.
- Kihi-to treatment restored neuritic and synaptic densities in the cerebral cortex and hippocampus.
- Kihi-to inhibited Aβ(25–35)-induced cell death in cultured cortical neurons.
- Kihi-to reduced calpain levels and increased calpastatin levels in the brain.
Takeaway
Kihi-to is a herbal medicine that helps mice with memory problems and damaged brain cells get better.
Methodology
The study used Alzheimer's disease model mice to test the effects of Kihi-to on memory and neurite growth, employing behavioral tests and immunohistochemistry.
Limitations
The study primarily focused on animal models, and further research is needed to confirm the effects in humans.
Participant Demographics
Male ddY mice, 7 weeks old.
Statistical Information
P-Value
p=0.004
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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