Inhibition of HIV-1 Infection by Sargassum fusiforme
Author Information
Author(s): Paskaleva Elena E, Lin Xudong, Li Wen, Cotter Robin, Klein Michael T, Roberge Emily, Yu Er K, Clark Bruce, Veille Jean-Claude, Liu Yanze, Lee David Y-W, Canki Mario
Primary Institution: Center for Immunology and Microbial Disease, Albany Medical College, Albany, NY, USA
Hypothesis
Can Sargassum fusiforme inhibit HIV-1 infection in various human cell types?
Conclusion
Sargassum fusiforme is a potent inhibitor of HIV-1 infection and replication in T cells, macrophages, microglia, and astrocytes.
Supporting Evidence
- Sargassum fusiforme extract blocked HIV-1 infection and replication by over 90% in T cells and human macrophages.
- It inhibited pseudotyped HIV-1 infection in human astrocytes by over 70%.
- The treatment did not inhibit cell growth or viability and was not toxic to cells.
- Sargassum fusiforme treatment blocked direct cell-to-cell infection spread.
Takeaway
Sargassum fusiforme, a type of seaweed, can help stop HIV from infecting important immune cells in the body.
Methodology
The study tested the effects of Sargassum fusiforme extract on HIV-1 infection in T cells, macrophages, microglia, and astrocytes using various assays to measure viral replication and cell viability.
Limitations
The exact mechanisms of inhibition and the potential for in vivo application need further investigation.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website