Study on ALG9 Variations and Bipolar Disorder
Author Information
Author(s): Baysal Bora E, Willett-Brozick Joan E, Bacanu Silviu-Alin, Detera-Wadleigh Sevilla, Nimgaonkar Vishwajit L
Primary Institution: The University of Pittsburgh
Hypothesis
Do common variations in the ALG9 gene predispose individuals to bipolar I disorder?
Conclusion
Common variations in ALG9 do not play a major role in predisposition to bipolar affective disorder.
Supporting Evidence
- The study tested five polymorphic markers spanning the ALG9 gene.
- Three common haplotypes were identified, but none showed significant association with bipolar I disorder.
- The results were consistent across two different pedigree series.
Takeaway
The study looked at a gene called ALG9 to see if it is linked to bipolar disorder, but they found no connection.
Methodology
The study used transmission disequilibrium tests to analyze genetic markers in two pedigree series.
Limitations
The study may not have enough power to detect rare susceptibility variants due to the sample size and structure of the pedigrees.
Participant Demographics
The majority of participants were of Caucasian descent.
Digital Object Identifier (DOI)
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