TCF12 and MALAT1 in Colorectal Cancer Prognosis
Author Information
Author(s): Wu Chia-Ming, Chen Chung-Hsing, Tsai Kuo-Wang, Tan Mei-Chen, Tsai Fang-Yu, Jiang Shih-Sheng, Chen Shang-Hung, Chen Wei-Shone, Wang Horng-Dar, Huang Tze-Sing
Primary Institution: National Health Research Institutes
Hypothesis
The TCF12–MALAT1 alliance is linked to poorer prognosis in colorectal cancer patients independently of metastasis.
Conclusion
The study identifies a subset of colorectal cancer patients with high TCF12 and MALAT1 expression but low β-catenin expression, associated with poor survival outcomes.
Supporting Evidence
- TCF12 and MALAT1 expression levels were significantly correlated in colorectal cancer tissues.
- Patients with high TCF12 and MALAT1 expression but low β-catenin expression had poorer overall survival.
- The TMBC pattern was identified as a significant risk factor for mortality in colorectal cancer patients.
Takeaway
Some colorectal cancer patients have a bad prognosis because of a combination of certain gene expressions, even if their cancer hasn't spread.
Methodology
The study used RNA sequencing and clinical data analysis from the TCGA-COAD dataset to investigate gene expression correlations and survival outcomes.
Limitations
The findings are based on a single dataset and lack exploration of the mechanisms behind the gene expression patterns.
Participant Demographics
The study included 193 colorectal cancer patients from the TCGA-COAD dataset.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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