Association of the Estrogen Receptor 1 Gene with Body Height in Adult Males
Author Information
Author(s): Andreas Dahlgren, Per Lundmark, Tomas Axelsson, Lars Lind, Ann-Christine Syvänen
Primary Institution: Uppsala University
Hypothesis
Is there an association between the ESR1 gene and body height in adult males?
Conclusion
The study found that certain genetic variants in the ESR1 gene are associated with increased body height in elderly males.
Supporting Evidence
- Four SNPs in the ESR1 gene showed suggestive association signals with body height.
- Homozygote carriers of the G-allele of SNP rs2179922 were taller than other genotypes.
- The study replicated findings in a second cohort, confirming the association.
Takeaway
Scientists looked at genes to see if they affect how tall men are. They found that one specific gene can make men a bit taller.
Methodology
The study involved genotyping SNPs in the ESR1 gene and analyzing their association with body height in two cohorts of elderly men.
Limitations
The study did not have sufficient power to detect small genetic effects on height in females.
Participant Demographics
Elderly men aged 70 from two Swedish population cohorts.
Statistical Information
P-Value
0.0056
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website