Exercise-induced intra-ventricular gradients as a frequent potential cause of myocardial ischemia in cardiac syndrome X patients
2008

Intra-ventricular Gradients in Cardiac Syndrome X Patients During Exercise

Sample size: 91 publication Evidence: moderate

Author Information

Author(s): Cotrim Carlos, Almeida Ana G, Carrageta Manuel

Primary Institution: Cardiology Department, Garcia de Orta Hospital, Almada, Portugal

Hypothesis

The study aims to assess the occurrence of intra-ventricular gradients during exercise stress echocardiography in cardiac syndrome X patients.

Conclusion

A significant number of patients with cardiac X syndrome developed intra-ventricular gradients during exercise, which may be associated with symptoms and specific echocardiographic findings.

Supporting Evidence

  • 36% of patients developed intra-ventricular gradients during exercise.
  • Patients with intra-ventricular gradients were younger and had different echocardiographic measurements compared to those without.
  • The presence of intra-ventricular gradients was associated with symptoms during exercise.

Takeaway

Some patients with a heart condition called cardiac syndrome X can have unusual pressure changes in their hearts when they exercise, which might make them feel pain.

Methodology

The study evaluated 91 patients with cardiac syndrome X using exercise stress echocardiography and Doppler echocardiographic evaluation.

Limitations

The study did not include tests for coronary spasm and excluded patients with left ventricular hypertrophy and uncontrolled hypertension.

Participant Demographics

Mean age 51 years, 44% women, with angina and normal coronary angiograms.

Statistical Information

P-Value

p<0.000

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1476-7120-6-3

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