Locally Weighted Transmission/Disequilibrium Test for Genetic Association Analysis
Author Information
Author(s): Hsu Li, Yu Xuesong, Houwing-Duistermaat Jeanine J, Uh Hae-Won, El Galta Rachid, Lebrec Jeremie JP, Tang Hua
Primary Institution: Fred Hutchinson Cancer Research Center
Hypothesis
Can a locally weighted approach improve the assessment of genetic associations in affected-parent trios?
Conclusion
The proposed method accounts for local dependencies among adjacent markers but did not show much more power than the conventional TDT.
Supporting Evidence
- The study analyzed data from 100 nuclear families with 283 affected offspring.
- The proposed method yielded a smoothed signal between markers B03T3056 and B03T3057.
- Marker D3S0124 exceeded the cut-off threshold for IBD testing.
- SNP B03T3056 showed significant associations with disease occurrence.
- The overall LOD score for microsatellite marker D3S0127 increased when including SNP B03T3056.
Takeaway
This study looks at how to better analyze genetic data to find out if certain genes are linked to a disease, using a new method that considers nearby markers.
Methodology
The study analyzed genetic data from affected-parent trios using a locally weighted transmission/disequilibrium test.
Limitations
The proposed method did not show much more power than the conventional TDT due to weak inter-marker linkage disequilibrium.
Participant Demographics
Participants were from Aipotu country, a semi-tropical, semi-desert region with a high prevalence of Kofendrerd Personality Disorder.
Statistical Information
P-Value
0.02
Confidence Interval
(0.53, 0.67)
Statistical Significance
p = 0.02
Digital Object Identifier (DOI)
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