Rationale and protocol of a trial for prevention of diabetic atherosclerosis by using antiplatelet drugs: study of Diabetic Atherosclerosis Prevention by Cilostazol (DAPC study)
2006

Study on Preventing Diabetic Atherosclerosis with Antiplatelet Drugs

Sample size: 408 publication Evidence: moderate

Author Information

Author(s): Yamasaki Yoshimitsu, Kim Young-Seol, Kawamori Ryuzo

Primary Institution: Osaka University Faculty of Medicine

Hypothesis

Can antiplatelet therapy effectively prevent atherosclerosis in diabetic patients?

Conclusion

The study aims to clarify the efficacy of aspirin and cilostazol in preventing diabetic atherosclerosis.

Supporting Evidence

  • The study is the first to use an online system for data pooling in an international clinical trial.
  • It aims to address the rising incidence of diabetic atherosclerosis in Eastern Asia.
  • The study design includes a two-year follow-up to assess the effectiveness of the treatments.

Takeaway

This study is trying to find out if two types of medicine can help people with diabetes avoid heart problems.

Methodology

Patients with type 2 diabetes were randomly assigned to receive either aspirin or cilostazol for two years.

Potential Biases

Potential bias in patient selection and reporting of outcomes.

Limitations

The study may not fully represent all diabetic patients due to specific inclusion and exclusion criteria.

Participant Demographics

Patients aged 40 to 85 with type 2 diabetes and signs of arteriosclerosis.

Statistical Information

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1186/1475-2840-5-16

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