Cyclin D1 and Bladder Cancer
Author Information
Author(s): Tut V M, Braithwaite K L, Angus B, Neal D E, Lunec J, Mellon J K
Primary Institution: University of Newcastle upon Tyne
Hypothesis
Can cyclin D1 expression levels in bladder cancer predict clinical outcomes?
Conclusion
Cyclin D1 expression is significantly higher in low-stage, well-differentiated bladder tumors and is an independent prognostic indicator of survival in muscle-invasive disease.
Supporting Evidence
- Positive staining for cyclin D1 was found in 83% of tumors.
- 89% of Ta/T1 tumors showed nuclear staining.
- The median value for cyclin D1 staining was significantly higher in Ta/T1 tumors compared to T2–T4 tumors.
- There was a significant positive correlation between expression of cyclin D1 and waf1 expression.
- A cyclin D1 index ≥ 8% was associated with significantly better survival in muscle-invasive disease.
Takeaway
This study found that a protein called cyclin D1 is more common in less severe bladder cancers and can help predict how well patients will do.
Methodology
Immunohistochemistry was used to stain paraffin sections from bladder tumors, and multivariate analyses were performed to assess risk factors for tumor recurrence and survival.
Participant Demographics
150 newly diagnosed bladder cancer patients.
Statistical Information
P-Value
P<0.0001
Statistical Significance
p<0.005
Digital Object Identifier (DOI)
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