Alcohol Lowers Seizure Threshold in Mice with Bupropion
Author Information
Author(s): Peter H Silverstone, Robert Williams, Louis McMahon, Rosanna Fleming, Siobhan Fogarty
Primary Institution: Biovail Corporation
Hypothesis
Does ethanol pretreatment affect bupropion HCl-induced seizures in mice?
Conclusion
Alcohol significantly lowers the seizure threshold for bupropion-induced seizures in mice.
Supporting Evidence
- Bupropion HCl alone induced seizures in a dose-dependent manner.
- Ethanol pretreatment increased the percentage of convulsing mice at all bupropion doses.
- The convulsive dose of bupropion HCl was reduced when combined with ethanol.
Takeaway
When mice were given alcohol before bupropion, they had more seizures. This means people taking bupropion should be careful with alcohol.
Methodology
Female Swiss albino mice received doses of bupropion HCl and ethanol, and seizures were recorded.
Limitations
The study was conducted only in mice, which may not fully represent human responses.
Participant Demographics
Experimentally naïve female Swiss albino mice, approximately 7 weeks old.
Statistical Information
P-Value
0.0019
Confidence Interval
CI: 107.95, 126.20
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website