Mitochondrial Localized STAT3 Is Involved in NGF Induced Neurite Outgrowth
2011
Mitochondrial STAT3 and Neurite Outgrowth
publication
Evidence: moderate
Author Information
Author(s): Lihan Zhou, Heng-Phon Too
Primary Institution: National University of Singapore
Hypothesis
P-Ser-STAT3 mediates NGF induced neurite outgrowth via a transcription-independent mechanism.
Conclusion
Mitochondrial localized P-Ser-STAT3 is involved in NGF induced neurite outgrowth through a novel mechanism.
Supporting Evidence
- NGF induced the phosphorylation of residue serine727 but not tyrosine705 of STAT3 in PC12 and primary cortical neuronal cells.
- Mitochondrial STAT3 was found to be involved in NGF induced neurite outgrowth and the production of reactive oxygen species (ROS).
- NGF induced P-Ser-STAT3 was localized to the mitochondria but not in the nucleus.
- Using mitochondria targeted STAT3 mutants, mitochondrial P-Ser-STAT3 was found to regulate NGF induced neurite outgrowth.
Takeaway
This study shows that a protein called STAT3, found in mitochondria, helps nerve cells grow when they are stimulated by a growth factor.
Methodology
The study involved experiments on PC12 cells and primary cortical neurons to assess the role of P-Ser-STAT3 in neurite outgrowth.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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