Nephrotoxicity of HAART
Author Information
Author(s): Kalyesubula Robert, Perazella Mark A.
Primary Institution: Makerere University College of Health Sciences
Hypothesis
How does highly active antiretroviral therapy (HAART) affect kidney function in HIV-infected patients?
Conclusion
HAART can lead to various forms of kidney dysfunction, necessitating regular monitoring and management.
Supporting Evidence
- HAART has been associated with acute kidney injury (AKI) in HIV-infected patients.
- Tenofovir is the drug most often associated with Fanconi syndrome.
- Kidney disease contributed to death in a minority of patients on HAART.
- Severe kidney dysfunction occurred in only 2.7% of patients on all regimens.
- AKI in hospitalized HAART naïve-HIV-1-infected patients is associated with a 6-fold higher risk of in-hospital mortality.
- Risk factors for nephrotoxicity include older age and preexisting kidney disease.
- Regular monitoring of kidney function is essential for patients on HAART.
Takeaway
Some medicines for HIV can hurt your kidneys, so doctors need to check kidney health regularly for people taking these medicines.
Methodology
The paper reviews existing literature and studies on the nephrotoxic effects of HAART.
Potential Biases
Potential bias in reporting due to the reliance on observational studies.
Limitations
Renal tubular function was not assessed in the DART trial.
Participant Demographics
Symptomatic ART-naive adults from Uganda and Zimbabwe with CD4 < 200 cells/mm3.
Statistical Information
P-Value
0.001
Confidence Interval
95% CI, 2.13–5.70 mL/min
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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