Clinical importance of patient-reported outcome measures in severe asthma: results from U-BIOPRED

2024

Understanding Patient-Reported Outcomes in Severe Asthma

Sample size: 421 publication 10 minutes Evidence: moderate

Author Information

Author(s): Roy Meys, Franssen Frits M.E., Van ‘t Hul Alex J., Bakke Per S., Caruso Massimo, Dahlén Barbro, Fowler Stephen J., Geiser Thomas, Howarth Peter H., Horváth Ildikó, Krug Norbert, Behndig Annelie F., Singer Florian, Musial Jacek, Shaw Dominick E., Montuschi Paolo, Zee Anke H. Maitland-van der, Sterk Peter J., Roberts Graham, Kermani Nazanin Z., Incalzi Raffaele A., Louis Renaud, Andersson Lars I., Wagers Scott S., Dahlén Sven-Erik, Chung Kian Fan, Adcock Ian M., Spruit Martijn A.

Primary Institution: Ciro, Horn, The Netherlands

Hypothesis

Do asthma exacerbations affect changes in patient-reported outcome measures (PROMs) over time, and can asthma-specific PROMs predict exacerbations in adults with severe asthma?

Conclusion

PROMs are significantly impaired in patients with severe asthma, and asthma exacerbations are key drivers of changes in these measures.

Supporting Evidence

Patients with no exacerbations showed significant improvement in PROMs.
Patients with more than two exacerbations experienced a deterioration in PROM scores.
Baseline ACQ5 was a predictor of exacerbations with low diagnostic accuracy.

Takeaway

This study shows that when asthma patients have flare-ups, their reported quality of life gets worse, but those without flare-ups feel better over time.