Predictors for Surfactant Retreatments in Preterm Infants
Author Information
Author(s): Dani Carlo, Poggi Chiara, Agosti Massimo, Bellettato Massimo, Betta Pasqua, Biban Paolo, Corvaglia Luigi, Falsaperla Raffaele, Forcellini Carlo, Gazzolo Diego, Gitto Eloisa, Gizzi Camilla, Lago Paola, Lista Gianluca, Maffei Gianfranco, Mosca Fabio, Napolitano Marcello, Scarpelli Gianfranco, Sandri Fabrizio, Trevisanuto Daniele, Vento Giovanni, Corsini Iuri, Pratesi Simone, Boni Luca
Primary Institution: Department of Neurosciences, Psychology, Drug Research and Child Health, University of Florence, Florence, Italy
Hypothesis
Can clinical predictors identify the need for multiple doses of surfactant in preterm infants with respiratory distress syndrome?
Conclusion
Gestational age, hypertension in pregnancy, and hemodynamically significant PDA can predict the need for multiple doses of surfactant.
Supporting Evidence
- 68% of infants were treated with a single dose of surfactant.
- 32% of infants required multiple doses of surfactant.
- Infants with higher gestational age had a lower odds of requiring multiple doses.
- Infants born to mothers with hypertensive disorders had a higher odds of requiring multiple doses.
- Infants with hemodynamically significant PDA had a higher odds of requiring multiple doses.
Takeaway
Doctors can tell if a preterm baby might need more surfactant medicine based on how early they were born and if their mom had high blood pressure.
Methodology
Data were analyzed from three previous studies on infants born between 25+0 and 31+6 weeks of gestation with RDS who were treated with surfactant.
Limitations
The study is a secondary analysis of data from three previous studies, limiting the evaluation of important variables.
Participant Demographics
Infants born between 25+0 and 31+6 weeks of gestation with respiratory distress syndrome.
Statistical Information
P-Value
P<0.001
Confidence Interval
95% C.l. 0.26–0.79; 95% C.l. 1.49–4.31; 95% C.l. 1.66–4.53
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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