International Stroke Trial Data Availability
Author Information
Author(s): Peter Sandercock, Maciej Niewada, Anna Członkowska
Primary Institution: Department of Clinical Neurosciences, University of Edinburgh
Hypothesis
Can individual patient data from the International Stroke Trial be made available for public use to facilitate future trials?
Conclusion
The IST dataset provides valuable primary data for planning further trials, especially in older patients and resource-poor settings.
Supporting Evidence
- The dataset includes data on 19,435 patients with acute stroke.
- 99% complete follow-up was achieved.
- Patients were treated 15-20 years ago, and many have died.
Takeaway
This study collected data from a large number of stroke patients to help researchers plan future studies and understand stroke treatment better.
Methodology
Data was extracted from randomised patients at multiple time points, including baseline, 14 days, and 6 months after randomisation.
Potential Biases
The unblinded data collection may introduce some bias.
Limitations
Consent for publication of raw data was not obtained from participants, and the study was conducted when stroke care was less advanced.
Participant Demographics
Over 26.4% of patients were aged over 80 years at study entry.
Digital Object Identifier (DOI)
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