Urinary Metabolite Profiles in Overweight and Obese Participants on a High Fruit and Vegetable Diet
Author Information
Author(s): Clarke Erin D., Gómez-Martín María, Stanford Jordan, Yilmaz Ali, Ustun Ilyas, Wood Lisa, Green Brian, Graham Stewart F., Collins Clare E.
Primary Institution: The University of Newcastle
Hypothesis
How do the urinary metabolomic profiles compare for participants prior to, during, and after a 10-week weight loss intervention where participants were prescribed a high fruit and vegetable diet?
Conclusion
The study found that urinary metabolites can serve as potential biomarkers of high fruit and vegetable intake, which is associated with reduced energy intake.
Supporting Evidence
- Energy intake was significantly lower at week 10 compared to baseline.
- Total fruit and vegetable intake was significantly higher at week 2 and week 10.
- 123 urinary metabolites were quantified during the study.
- 21 metabolites showed significant changes at week 10 relative to baseline.
Takeaway
Eating more fruits and vegetables can change what your body produces in urine, which might help us understand how healthy eating affects weight.
Methodology
Participants were prescribed a high fruit and vegetable diet for 10 weeks, with urine samples collected at baseline, week 2, and week 10 to analyze metabolite changes.
Potential Biases
Potential bias due to the lack of a control group and the feasibility nature of the study.
Limitations
The study used spot urine samples instead of 24-hour collections, had a small sample size, and lacked a control group.
Participant Demographics
Adults aged 18-45 years with a BMI between 25 and 35 kg/m2.
Statistical Information
P-Value
0.02
Confidence Interval
95% CI 97–99%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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