Effects of Tumors on Mouse Blood and Urine Analytes
Author Information
Author(s): P.R.N. Kind, M. Gordon, M. Laverick, A.H.W. Nias, B.M. Slavin
Primary Institution: St. Thomas's Hospital Medical School
Hypothesis
Tumor-bearing mice will show different serum and urine analyte levels compared to normal mice.
Conclusion
Tumor-bearing mice exhibited lower levels of certain serum proteins and higher aspartate transaminase compared to normal mice.
Supporting Evidence
- Serum total protein, alanine transaminase, and alkaline phosphatase were lower in tumor-bearing mice.
- Aspartate transaminase was higher in tumor-bearing mice.
- Urine protein and N-acetyl-β-D-glucosaminidase activity were lower in male tumor-bearing mice.
- Alkaline phosphatase levels decreased with age in normal mice.
- Significant differences were found between normal and tumor-bearing mice for several analytes.
Takeaway
Mice with tumors have different blood and urine test results than healthy mice, which helps us understand how cancer affects the body.
Methodology
C3H mice were implanted with mammary tumors, and serum and urine analytes were measured and compared with age and sex matched controls.
Potential Biases
Potential bias in the selection of control groups and the method of blood collection.
Limitations
The study may not account for all variables affecting analyte levels, and results are specific to the C3H mouse strain.
Participant Demographics
C3H mice, both male and female, aged 10-30 weeks.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Want to read the original?
Access the complete publication on the publisher's website