Antimycobacterial Activity of Bridelia micrantha
Author Information
Author(s): Green Ezekiel, Obi Lawrence C, Samie Amidou, Bessong Pascal O, Ndip Roland N
Primary Institution: AIDS Virus Research Laboratory, Department of Microbiology, University of Venda
Hypothesis
The n-Hexane sub-fraction from Bridelia micrantha has antimycobacterial activity against Mycobacterium tuberculosis.
Conclusion
The n-Hexane fraction of B. micrantha has demonstrated significant antimycobacterial activity.
Supporting Evidence
- The n-Hexane fraction showed 20% inhibition of MTB H37Ra.
- The fraction inhibited almost 35% of an MTB isolate resistant to all first-line drugs at 10 μg/mL.
- Twenty-four constituents were identified in the n-Hexane fraction, representing 60.5% of the fraction.
Takeaway
This study found that a part of the Bridelia micrantha plant can help fight a bacteria that causes tuberculosis.
Methodology
The study evaluated the antimycobacterial activity using the resazurin microplate assay against two MTB isolates.
Limitations
The study did not assess the toxicity of the essential oils and their complex mixtures.
Statistical Information
P-Value
0.0012
Confidence Interval
95% CI 1.37-2.46
Statistical Significance
p=0.0012
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website