Soluble fibrin inhibits monocyte adherence and cytotoxicity against tumor cells: implications for cancer metastasis
2006
Soluble Fibrin and Its Role in Cancer Metastasis
publication
Evidence: moderate
Author Information
Author(s): Biggerstaff John P, Weidow Brandy, Vidosh Jacqueline, Dexheimer Judith, Patel Shonak, Patel Pretesh
Primary Institution: University of Tennessee
Hypothesis
Soluble fibrin may inhibit leukocyte adherence, recognition, and killing of tumor cells.
Conclusion
Soluble fibrin inhibits monocyte adherence and cytotoxicity of tumor cells, suggesting its role in cancer metastasis.
Supporting Evidence
- Soluble fibrin enhances metastasis by inhibiting immune cell functions.
- Blocking specific receptors can restore immune cell adherence to tumor cells.
- High levels of soluble fibrin in cancer patients may lead to immunosuppression.
Takeaway
Soluble fibrin can stop immune cells from sticking to and killing cancer cells, which might help cancer spread.
Methodology
The study used microplate adherence and cytotoxicity assays, along with flow conditions in a microscope perfusion incubator.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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