eNOS Gene Variant and Heart Attack Risk in Diabetics
Author Information
Author(s): Odeberg Jacob, Larsson Charlotte A, Råstam Lennart, Lindblad Ulf
Primary Institution: Karolinska Institutet, University Hospital, Stockholm, Sweden
Hypothesis
Does the eNOS Asp298 allele increase the risk of myocardial infarction in patients with type 2 diabetes mellitus?
Conclusion
The study found a strong link between the eNOS Asp298 allele and increased risk of myocardial infarction in patients with type 2 diabetes.
Supporting Evidence
- Homozygosity for the eNOS Asp298 allele significantly increased the risk of myocardial infarction in patients with type 2 diabetes.
- All patients with type 2 diabetes had a higher risk of myocardial infarction compared to non-diabetic subjects.
- The risk was particularly pronounced in women with type 2 diabetes carrying the Asp298 allele.
Takeaway
People with type 2 diabetes who have a specific gene variant are at a higher risk of having a heart attack.
Methodology
The study analyzed data from 403 patients with type 2 diabetes and 799 healthy controls to assess the relationship between the eNOS Asp298 allele and myocardial infarction risk.
Potential Biases
Stratification into T2DM, genotype, and sex resulted in small numbers within groups, which may affect the robustness of the findings.
Limitations
The study did not follow the health status of the control population regarding diabetic status after baseline surveillance.
Participant Demographics
The study included 202 men and 201 women with type 2 diabetes, and 391 men and 408 women as controls.
Statistical Information
P-Value
0.003
Confidence Interval
[1.49–6.56]
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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