Effects of Atorvastatin on Endothelial Function in Heart Disease Patients
Author Information
Author(s): Yildiz Ahmet, Cakar M Akif, Baskurt Murat, Okcun Barıs, Guzelsoy Deniz, Coskun Ugur
Primary Institution: Gazi Hospital, İzmir, Turkey; Institute of Cardiology, İstanbul University, İstanbul, Turkey
Hypothesis
The study aims to evaluate the effect of atorvastatin therapy on endothelial functions in patients with coronary artery disease (CAD).
Conclusion
Atorvastatin therapy significantly improved endothelial function in patients with CAD over 12 weeks.
Supporting Evidence
- Atorvastatin caused a significant decrease in LDL-cholesterol and total cholesterol levels.
- Endothelium dependent vasodilatation improved significantly after 12 weeks of atorvastatin therapy.
- No significant change was observed in non-endothelium dependent dilatation.
Takeaway
This study found that taking atorvastatin helps improve the blood vessels' ability to relax in people with heart disease.
Methodology
Patients with CAD were given atorvastatin for 12 weeks, and endothelial function was assessed using flow mediated dilatation (FMD) of the brachial artery.
Limitations
The study excluded patients with recent surgeries or other significant health issues, which may limit generalizability.
Participant Demographics
40 men and 9 women, mean age 59 years.
Statistical Information
P-Value
p < 0.0001
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
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