Bone Marrow Stromal Cell Transplantation Mitigates Radiation-Induced Gastrointestinal Syndrome in Mice
Author Information
Author(s): Saha Subhrajit, Bhanja Payel, Kabarriti Rafi, Liu Laibin, Alfieri Alan A., Guha Chandan
Primary Institution: Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York, United States of America
Hypothesis
Can bone marrow-derived adherent stromal cell transplantation mitigate radiation-induced gastrointestinal syndrome (RIGS) in mice?
Conclusion
Transplantation of bone marrow-derived stromal cells can effectively mitigate lethal intestinal injury caused by high doses of radiation.
Supporting Evidence
- BMASCT improved survival rates in irradiated mice from 0% to 100%.
- Histopathological analysis showed significant intestinal regeneration in BMASCT-treated mice.
- Serum levels of intestinal growth factors increased significantly after BMASCT.
Takeaway
This study shows that giving special cells from bone marrow to mice after they get a lot of radiation can help their intestines heal and keep them alive.
Methodology
Mice were given lethal doses of radiation and then treated with cultured bone marrow-derived stromal cells to assess survival and intestinal recovery.
Limitations
The study was conducted in mice, and results may not directly translate to humans.
Participant Demographics
C57Bl/6 male mice, aged 5-6 weeks.
Statistical Information
P-Value
p<0.0007
Statistical Significance
p<0.0007
Digital Object Identifier (DOI)
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