Using Tranexamic Acid to Reduce Blood Loss in Knee Surgery
Author Information
Author(s): Mandeep S Dhillon, Kamal Prabhakar Bali, Sharad Prabhakar
Primary Institution: Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
Hypothesis
Administration of TEA to patients undergoing bilateral TKA in a single stage would help reduce postoperative blood loss and decrease allogenic blood transfusion requirements.
Conclusion
TEA administered in patients undergoing single stage bilateral TKA helped reduce total blood loss and decreased allogenic blood transfusion requirements.
Supporting Evidence
- Patients receiving TEA had a significantly lower total drain output compared to controls.
- All patients in the control group required blood transfusions, while 25 patients in the TEA group did not.
- The postoperative hemoglobin levels were significantly lower in the control group.
Takeaway
This study shows that giving a medicine called tranexamic acid can help patients who have knee surgery lose less blood and need fewer blood transfusions.
Methodology
A case control study comparing 52 patients receiving TEA with 56 matched controls who did not receive TEA.
Potential Biases
The case control design may introduce bias as it did not allow for randomization.
Limitations
The study did not measure intraoperative blood loss, which could affect total blood loss calculations.
Participant Demographics
Patients with primary osteoarthritis of the knee undergoing simultaneous bilateral TKA.
Statistical Information
P-Value
0.000
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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