The TCF7L2 locus and type 1 diabetes
2007
The TCF7L2 Gene and Type 1 Diabetes
Sample size: 886
publication
Evidence: moderate
Author Information
Author(s): Qu Hui-Qi, Polychronakos Constantin
Primary Institution: The McGill University Health Center (Montreal Children's Hospital)
Hypothesis
Is there a genetic association between TCF7L2 and type 1 diabetes?
Conclusion
The study suggests that TCF7L2 does not play a role in the etiology of type 1 diabetes.
Supporting Evidence
- The study found no association between TCF7L2 and type 1 diabetes.
- The age-of-onset effect from TCF7L2 variation was also not observed.
- The minor allele frequency of rs7903146 was similar to control groups in T2D studies.
Takeaway
The researchers looked at a gene thought to be linked to diabetes but found it doesn't affect type 1 diabetes.
Methodology
Genotyping of SNP rs7903146 in 886 T1D nuclear family trios.
Limitations
The study only examined one SNP and may not account for other genetic factors.
Participant Demographics
Participants were of mixed European descent, primarily Quebec French-Canadian.
Statistical Information
P-Value
0.311
Statistical Significance
p=0.311
Digital Object Identifier (DOI)
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