Prognostic Value of 90K Antigen in Breast Cancer
Author Information
Author(s): S. Iacobelli, P. Sismondi, M. Giai, M. D'Egidio, N. Tinari, C. Amatetti, P. Di Stefano, C. Natoli
Primary Institution: University G. D'Annunzio Medical School
Hypothesis
Can circulating levels of 90K influence the prognosis of patients with breast cancer?
Conclusion
An elevated 90K antigen level in serum is a predictor of poor prognosis in breast cancer.
Supporting Evidence
- 90K levels were positive in 18.5% of patients with no evidence of disease after surgery.
- Patients with elevated 90K levels had a 75-month overall survival of 53%, compared to 78% for those with lower levels.
- High 90K levels were significantly associated with the presence of metastases to the liver.
Takeaway
This study found that a protein called 90K in the blood can help doctors understand how serious breast cancer is for patients.
Methodology
Serum samples were collected from breast cancer patients and analyzed for 90K levels using an immunoradiometric assay.
Limitations
The study did not evaluate the utility of 90K for monitoring the clinical course of patients with breast cancer.
Participant Demographics
735 female breast cancer patients with a mean age of 59 years.
Statistical Information
P-Value
0.001
Statistical Significance
p<0.05
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