Fecal Bile Acids and Colorectal Cancer Risk
Author Information
Author(s): Yang Shaohui, Wang Yu, Sheng Lijuan, Cui Wei, Ma Chenyang
Primary Institution: Ningbo Medical Center Lihuili Hospital
Hypothesis
Is there a correlation between fecal bile acid concentrations and the risk of colorectal cancer?
Conclusion
Higher fecal concentrations of bile acids may be associated with an increased risk of colorectal cancer.
Supporting Evidence
- Individuals with high risk of colorectal cancer had higher concentrations of fecal bile acids than those at low risk.
- The study included 23 observational studies with a total of 1265 participants.
- Meta-analysis showed significant differences in bile acid concentrations between high-risk and low-risk groups.
- Different detection methods were used across studies, which may affect the results.
Takeaway
This study found that people with higher levels of certain bile acids in their poop might be more likely to get colon cancer.
Methodology
The study performed a systematic review and meta-analysis of cross-sectional and case-control studies to assess the relationship between fecal bile acids and colorectal cancer.
Potential Biases
Different studies had varying detection methods, which may affect the accuracy of results.
Limitations
The study included various detection methods and had unavoidable information bias and confounding bias.
Participant Demographics
The studies included participants from multiple countries, including China, the UK, the USA, France, Japan, Germany, and Zimbabwe.
Statistical Information
P-Value
0.02 for CA, 0.009 for CDCA, 0.03 for DCA, 0.005 for UDCA, p<0.00001 for combined effect size in high-risk vs. low-risk groups.
Confidence Interval
95% CI: 0.5–0.76 for CA, 95% CI: 0.09–0.62 for CDCA, 95% CI: 0.03–0.64 for DCA, 95% CI: 0.14–0.78 for UDCA.
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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