Iridoid Glycosides from Folium Syringae Leaves Help Treat Colitis
Author Information
Author(s): Liu Xin, Wang Jian Ming
Primary Institution: Zhejiang University, Hangzhou, China
Hypothesis
Iridoid glycosides modulate the inflammatory response in experimental colitis through the NF-κB signaling pathway and epithelial cell apoptosis.
Conclusion
Iridoid glycosides significantly protect against experimental colitis by inhibiting epithelial cell apoptosis and blocking the NF-κB signaling pathway.
Supporting Evidence
- Iridoid glycosides significantly reduced the activity of myeloperoxidase, indicating lower inflammation.
- Treatment with iridoid glycosides decreased the levels of pro-inflammatory cytokines in a dose-dependent manner.
- Iridoid glycosides inhibited epithelial cell apoptosis as shown by reduced TUNEL-positive cells.
Takeaway
This study shows that a natural compound from a plant can help reduce inflammation and cell death in a type of bowel disease.
Methodology
Rats were induced with colitis using dextran sulfate sodium and treated with varying doses of iridoid glycosides, followed by assessments of inflammation and apoptosis.
Limitations
The study was conducted in a rat model, which may not fully replicate human conditions.
Participant Demographics
Male Sprague-Dawley rats, weighing 200–220 g.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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