MMP-7 and MMP-9 in Superficial Oesophageal Cancer
Author Information
Author(s): Yoshida T, Tanioka Y, Yagawa T, Saiki Y, Takeo S, Harada T, Okazawa T, Yanai H, Okita K
Primary Institution: Yamaguchi University School of Medicine
Hypothesis
The expression of matrix metalloproteinases MMP-7 and MMP-9 is associated with lymph node metastasis and prognosis in superficial oesophageal cancer.
Conclusion
MMP-7 and MMP-9 expression are significant markers for predicting prognosis and lymph node metastasis in superficial oesophageal cancer.
Supporting Evidence
- MMP-7 expression was found in 23.6% of cases and was significantly correlated with positive nodal metastasis.
- MMP-9 expression was observed in 47.3% of cases and was significantly related to deep invasion and positive lymphatic permeation.
- Coexpression of MMP-7 and MMP-9 was significantly correlated with deep tumour invasion and positive nodal metastasis.
Takeaway
This study found that two proteins, MMP-7 and MMP-9, can help doctors understand how serious a patient's oesophageal cancer is and if it has spread.
Methodology
The study retrospectively analyzed MMP-7 and MMP-9 expression in tissue samples from 55 patients with superficial oesophageal cancer treated by endoscopic and surgical resection.
Limitations
The study only included patients from a single institution and focused on superficial oesophageal cancer, which may limit the generalizability of the findings.
Participant Demographics
Average age 65.2 years, 41 males and 14 females.
Statistical Information
P-Value
p=0.004 for MMP-7 and nodal metastasis; p=0.001 for MMP-9 and lymphatic permeation.
Confidence Interval
(1.75∼18.444)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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