Reduced GNG7 Expression in Oesophageal Cancer
Author Information
Author(s): Ohta M, Mimori K, Fukuyoshi Y, Kita Y, Motoyama K, Yamashita K, Ishii H, Inoue H, Mori M
Primary Institution: Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
Hypothesis
The significance of GNG7 expression in oesophageal cancer is unknown.
Conclusion
GNG7 suppression is associated with poorer survival and greater invasiveness in oesophageal cancer.
Supporting Evidence
- 27 patients with low GNG7 expression showed significantly poorer survival than did 28 patients with high expression.
- Tumours with low GNG7 expression invaded deeper than those with high GNG7 expression.
- 57% of tumours with GNG7 suppression showed either loss of heterozygosity or promoter hypermethylation.
Takeaway
This study found that a gene called GNG7 is often less active in oesophageal cancer, which can make the cancer worse and harder to treat.
Methodology
TaqMan quantitative real-time PCR was performed on 55 cases of oesophageal cancer to assess GNG7 expression.
Participant Demographics
55 Japanese patients (47 men and 8 women; median age 61 years; range 40–82 years)
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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